Abstract

ANTI-ANGIOGENIC SCREENING OF NOVEL PYRAZOLINE DERIVATIVE

*Karishma Singh, Rohang Shukla and Dr. M. P. Toraskar

ABSTRACT

The process of vessel formation, called angiogenesis, is essential for tumor progression. Angiogenesis has also been associated with several pathological condition such as cancer. Targeting of molecular pathways involved in such tumor angiogenetic processes by using specific drugs or inhibitors is important for developing new anticancer therapies. Researchers need to use animal models that facilitate the elucidation of tumor angiogenesis mechanisms. VEGFR is an important growth factor and a positive regulator of angiogenesis with its distinct activity for vascular endothelial cells. It’s been observed that the zebrafish emerged as a valid model organism to study developmental angiogenesis and more recently has been developed for in vivo screening of anticancer agents having VEGFR inhibitory activity. The ablility of zebra fish to recapitulate a variety of human cancers provide a unique in vivo system for drug identification and validation. The current work is small effort to check the anti-angiogenic activity of synthesized drug using zebra fish model. The synthesized drug was found to have VEGFR inhibitory action.Thus the synthesized molecule hold importance as a lead to develop further molecules having anti-VEGFR activity and may be screened for its anti-cancer activity in future.

Keywords: Cancer cells, Angiogenesis, Zebra fish model.