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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Scope Indexed

WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2025 Issue has been successfully launched on 1 NOVEMBER 2025.

Abstract

ONE-POT SOLVENT-FREE SYNTHESIS, CYTOTOXICITY AND IN VITRO UREASE INHIBITORY ACTIVITY OF ZINC (II)-PIROXICAM COMPLEX

Muhammad Amin*

ABSTRACT

The solvent-free preparation and characterization of zinc(II)-piroxicam complex, Zn-pir, is described. After comparison of the data of solventfree, one-drop-solvent and solution products it was found that the complex is of ML2 type. Zn-pir was found less toxic than parent drug as evaluated by LD50 values. In Helicobacter pylori urease inhibitory activity, Zn-pir showed significant inhibition. The results of this investigation suggest that Zn-pir can be developed as a safer antiulcer and anti-inflammatory agent.

Keywords: Piroxicam, Zinc complexes, NSAIDs, mechanochamical synthesis, urease inhibitory activity.

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