Abstract

NASAL DRUG DELIVERY: A PROMISING APPROACH FOR BRAIN TARGETING

Devika Lomate, Arun Mahajan* and Mayuri Tapkir

ABSTRACT

The delivery of potential therapeutic moieties to brain is restricted by the Blood Brain Barrier. Approximately 1.5 billion people undergoing from disorder of CNS, these disorders needed to be cured by proper drug delivery to brain. Recently CNS disorders, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, depression, anxiety, seizures, epilepsy, migraine, etc can be effectively treated by intranasal drug delivery to brain and CNS. Intranasal route of delivery facilitates direct delivery of drug to the brain without systemic absorption, thus enhancing the efficacy and decreasing the side effects of neurotherapeutics. The olfactory and the trigeminal neural pathways enable direct targeting drug to the brain by passing the BBB, this has gained an important consideration for delivery of wide range of therapeutic moieties to brain. This short review aims to known basically the barriers for nasal drug delivery, crucial factors for nasal formulations and some advantages and disadvantages of intranasal drug delivery system.

Keywords: Intranasal drug delivery, Blood Brain Barrier, bioavailability, olfactory and trigeminal pathways.