Abstract

ORODISPERSIBLE TABLET: AN UPDATED REVIEW ON BUCCAL DRUG DELIVERY SYSTEM

*Prashant Bisht and Chandni Grover

ABSTRACT

Oral drug delivery remains the preferred route for administration of various drugs. Recent developments in the technology have prompted scientists to develop orally disintegrating tablets (ODTs) with improved patient compliance and convenience. ODTs are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. Orally disintegrating tablets provide an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules. This review describes the various formulation aspects, disintegrants employed and technologies developed for ODTs, along with various excipients, evaluation tests, marketed formulations, and drugs explored in this field. Orodispersible drug delivery systems for customized small scale pharmacy preparations. The aim is to develop a versatile casting solution suitable for the extemporaneous production of ODTs to which active pharmaceutical ingredients (APIs) can be added. Different combinations of superdisintegrant and other excipients and different casting heights were tested for their suitability for production of ODTs. Superdisintegrant and disintegrating agent used to prepare ODTs containing water-soluble APIs and a poorly water-soluble API for which ethanol 96% was used as co-solvent. In conclusion, ODTs of good pharmaceutical quality can be prepared on small scale. Hereby opening the perspective of using ODTs for individualized pharmacotherapy.

Keywords: Orodispersible, buccal drug delivery, superdisintegrant, solubility.