Abstract

LIQUE SOLID COMPACT DRUG DELIVERY SYSTEM: A REVIEW

*Mayuri Tapkir, Arun Mahajan, and Devika Lomate

ABSTRACT

Drugs which are orally administered possess the solubility is one of the major problem, because of the drugs with the low aq. solubility, such drugs get slowly dissolve and leads to low bioavailability. So, it is the biggest provocation in front of the scientists to improve the solubility of such drugs. Nearly about 40-50% of the drugs shows this problem. SEDDS is novel approach for improving the solubility of the lipophilic drug. The special feature of this delivery system is its ability to self-emulsify, that is their propensity to form oil-in-water emulsion on gentle agitation when diluted with aq. phase present outside the gastrointestinal tract. SEDDS possess low cost including easily available excipients such as natural oils or synthetic oil, surfactant, co-surfactant/ co-solvent. The major advantage of SEDDS is that it avoid the first pass effect and get absorbed by the lymphatic pathways. In this review we present a report on the formulation characterization, different dosage forms and application of SEDDS with examples of currently available marketed preparations.

Keywords: Self emulsifying drug delivery, Bioavailability and Solubility enhancement.