Abstract

REVIEW ON BUCCUL PATCHES AS A NOVEL DRUG DELEVERY SYSTEM

Bhupendra M. Mahale*, Devendra S. Mahale, Azam Z. Shaikh, Dr. J. A. Sawale

ABSTRACT

Buccal drug delivery systems relate with the mucus layer casing the mucosal epithelial superficial, and mucin molecules and rise the residence time of the dosage form at the location of absorption. The objective of this article is to review buccal drug delivery talk over the structure and environment of the oral mucosa and methodology in evaluating buccal formulations. This review also places of interest in a brief description of advantages, limitations of buccal drug delivery. The drugs which have native action or those which have extreme absorption in gastrointestinal tract (GIT) need to increased period of stay in GIT. Thus, buccal dosage forms are advantageous in enhancing the drug plasma concentrations and also therapeutic activity. Buccal Patches are the type of drug formulation that has normally a different way of administration through the buccal mucosa for drug delivery. These patches have a tendency to assistance drug enter directly the systemic circulation fugitive hepatic first pass metabolism.

Keywords: Buccal Delivery, Oral Mucosa, Mucoadhesion and Bio-adhesive Polymers. Buccal Patches, Bioavailability.