Abstract

DRUGGABILITY OF SOME UNEXPLOITED PROTEINS OF MYCOPLASMA PNEUMONIAE M129

Zahra M. Al-Khafaji*, Zainib H. A. Al-Rikabi, Marium B. Mahmood

ABSTRACT

Mycoplasma pneumoniae accused for some serious diseases inhuman, drug resistance of M. pneumoniae started to appear in someparts of the world . M. pneumoniae gets many hypothetical proteinswhich could represent drug targets . First step in drug design /discovery starts with estimation of target protein druggability (DrugScore). This study aimed to investigate druggability of M.pneumoniae M129 hypothetical proteins using DoGSiteScorer server. Different relationships between protein descriptors was studied .Strategic proteins were chosen for further studies , and those wereproteins with high number of interactions with other proteins , secondlevel of filtering was to chose membrane proteins and transporters .Results revealed that the proteins : MPN313 , MPN657, MPN661, MPN152, MPN244,PN268, MPN269, MPN400, MPN489, MPN570, MPN647, MPN648, MPN666 are suitablefor further investigations such as looking for suitable ligands and their docking to find outnew inhibitors .

Keywords: Mycoplasma pneumoniae, hypothetical proteins, druggability, drug targets , drug design/ discovery , DoGSiteScorer server .