Abstract

HEPATOPROTECTIVE EFFECT OF CLEOME GYNANDRA ON PARACETAMOL INDUCED HEPATOTOXICITY IN WISTAR RATS

K. Naga Harikrishna*, G. Pitchaiah, and D. Dhachinamoorhti

ABSTRACT

The present investigation was meant to investigate the hepatoprotective and cancer prevention agent movement of Cleome gynandra alcoholic extract in rats. The intense harmfulness studies were directed according to OECD rules 423 for 2000 mg/kg portion of Cleome gynandra extract. It was discovered that the extract even at 2000 mg/kg portion had not demonstrated any mortality affirming it's for all intents and purposes non-harmful in nature. The Cleome gynandra extract has hepatoprotective action. Cleome gynandra extract has a measurably critical hepatoprotective action as prove by counteractive action in the height of serum biochemical parameters like SGPT, SGOT, ALP and BIT in ethanol actuated hepatotoxicity in rats which were contrasted and standard Silymarin sedate. The Cleome gynandra extract has cancer prevention agent movement practically identical to standard ascorbic acid. The amounts of the Cleome gynandra extract required for the in vitro hindrance (IC50) of hydroxyl radicals and lipid peroxidation were nearer to the known cancer prevention agent ascorbic acid which confirms that Cleome gynandra extract has noteworthy cell reinforcement movement.

Keywords: Cleome Gynandra, Alcoholic extract, hepatioprotective activity.