Abstract

FORMULATION & EVALUATION OF METHOTREXATE CREAM

Priyadharshini J.*, Mohammed Halith S., Nagarajan M., Shobana M. and Aruna A.

ABSTRACT

The present work was carried out to prepare and evaluate the topical cream of methotrexate by using oil in water type. The cream was prepared by using cetyl alcohol, stearic acid, propylene glycol, glycerin, methyl and propyl paraben. The cream was evaluated by using physicochemical parameters (Spreadability, PH, Drug content & uniformity, Viscosity and stability studies). Methotrexate cream was formulated in oil in water type. As the resulting in 77.99% release of methotrexate at 7hr. Hence the formulation will produce fruitful results and will improve the patient compliance.

Keywords: Mehotrexate, Stearic acid, Physicochemical parameters.