ORAL BIOAVAILABILITY OF CEFADROXIL IN HEALTHY BROILER CHICKENS
Ashraf Elkomy, Faten Elsayed, Mohamed Elbadawy, Mohamed Aboubakr and Elrefaey Aboelftouh*
ABSTRACT
The pharmacokinetic parameters of cefadroxil (20 mg/kg bwt) were
studied following single intravenous (IV) and oral (PO)
administrations in healthy broiler chickens. Following a single IV
injection of cefadroxil at a dose of 20 mg/kg bwt in healthy chickens,
cefadroxil could be detected therapeutically for 24 h. The serum
concentration–time curve of cefadroxil following IV injection showed
that, the drug obeyed a two compartments open model and the
elimination half-life (t0.5β) was 4.85 h, volume of distribution (Vdss)
was 629 ml/kg and total body clearance (CLtot) of cefadroxil was 0.185
L/h/kg). Following a single PO administration of 20 mg cefadroxil /kg
bwt in healthy chickens, the peak serum concentration (Cmax) was
15.59 μg/ml was achieved at a maximum time (Tmax) of 1.47 h. The
oral bioavailability of cefadroxil in healthy chickens was 77.18%.
Keywords: Pharmacokinetics, cefadroxil, chickens.
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