Abstract

FORMULATION AND EVALUATION OF MODIFIED RELEASE ORAL HYDROGEL BEADS OF ANTIDIABETIC DRUG

Pitta. Lavanya*, K. Raja rajeswari, and B. Ramesh

ABSTRACT

The present study was aimed to Formulate and evaluate modifiedrelease oral Hydrogel Beads of an anti diabetic drug. The hydrogel beads were synthesized by physical cross-linking polymerization technique using, N,N′-Methylene bis acryl amide as cross linker. Ammonium persulphate was used as polymerization initiator to polymerize acrylic acid (AAc) to poly(acrylic acid) in presence of sodium alginate to form a polymeric network. The compatibility of drug with the polymers was confirmed by Fourier transform infrared spectroscopy (FT-IR) and Differential scanning calorimetric (DSC), studies were carried out to check the nature of the drug in the hydrogel beads formulations. Surface morphology was studied by using Scanning electron microscopy (SEM). The swelling studies showed a higher swelling in basic pH and a minimal swelling in acidic pH. From the swelling ratio it was found that the swelling of the hydrogel beads were pH depended and at PKa value (3-4) of acrylic acid the swelling showed a decreased value. From the diffusion study it was concluded that as the acrylic acid concentration increased and cross linker decreased the diffusion coefficient was increased. The in- vitro release data showed that, as the concentration of Cross-linking agent was increased; swelling decreased resulting in decreased release of the drug. From the results, it can be deduced that the acrylic acid-Sodium alginate hydrogel beads could be suitable as a controlled drug delivery system for the anti diabetic drug Gliclazide.

Keywords: Gliclazide, acryl amide polyethelenglycol potassium persulphate.