Photo Gallery



News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • MAY 2021 Issue has been successfully launched on 1 May 2021.



Pitta. Lavanya*, K. Raja rajeswari, and B. Ramesh


The present study was aimed to Formulate and evaluate modifiedrelease oral Hydrogel Beads of an anti diabetic drug. The hydrogel beads were synthesized by physical cross-linking polymerization technique using, N,N′-Methylene bis acryl amide as cross linker. Ammonium persulphate was used as polymerization initiator to polymerize acrylic acid (AAc) to poly(acrylic acid) in presence of sodium alginate to form a polymeric network. The compatibility of drug with the polymers was confirmed by Fourier transform infrared spectroscopy (FT-IR) and Differential scanning calorimetric (DSC), studies were carried out to check the nature of the drug in the hydrogel beads formulations. Surface morphology was studied by using Scanning electron microscopy (SEM). The swelling studies showed a higher swelling in basic pH and a minimal swelling in acidic pH. From the swelling ratio it was found that the swelling of the hydrogel beads were pH depended and at PKa value (3-4) of acrylic acid the swelling showed a decreased value. From the diffusion study it was concluded that as the acrylic acid concentration increased and cross linker decreased the diffusion coefficient was increased. The in- vitro release data showed that, as the concentration of Cross-linking agent was increased; swelling decreased resulting in decreased release of the drug. From the results, it can be deduced that the acrylic acid-Sodium alginate hydrogel beads could be suitable as a controlled drug delivery system for the anti diabetic drug Gliclazide.

Keywords: Gliclazide, acryl amide polyethelenglycol potassium persulphate.

[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More