Abstract

EFFECT OF ALCOHOLIC EXTRACT OF TERMINALIA BELLIRICA ROXB. IN DEXTRAN SULFATE SODIUM INDUCED COLITIS

Jigar S. Desai*, Sugandha Chaudhari, Aditya Adam, Harsha Chaudhari.

ABSTRACT

Aim: To evaluate the effectiveness of alcoholic extract of Terminalia bellirica Roxb.(TBAE) in dextran sulfate sodium induced colitis Method: Experimental colitis was induced by giving mice drinking water ad libitum containing 3.5% (w/v) Dextran sulfate sodium (DSS) for 7 days. Standard drug and extract administered concomitantly. The animals were sacrificed 24 h after the last dose administration & Disease parameters were studied. Result: Disease activity index, macroscopic score, microscopic score, MPO and colon length were showed recovery of disease with significant effectiveness from 7th, 5th & 4th day in 100 mg/kg dose, 250 & 500mg/kg dose and Mesalamine (100 mg/kg dose) respectively. Conclusion: TBAE shows effectiveness in dose dependent manner. TBAE 500 mg/kg provides better protection and is comparable to the standard drug- Mesalamine.

Keywords: Colitis, Dextran sulfate sodium, Myeloperoxidase, Terminalia bellirica