Abstract

ANTIHYPERTENSIVE ACTIVITY OF CYPERUS ROTUNDUS RHIZOME EXTRACTS ON ETHANOL- INDUCED HYPERTENSION IN WISTAR RATS

Shivi Agarwal*, Farheen Shareef and Saurabh Sharma

ABSTRACT

Hypertension is a very common condition that can lead to many health problems. This study aimed to evaluate the curative effects of the hydroalcoholic extract of Cyperus rotundus on hypertension. Hypertension was induced in rats by oral administration of ethanol (5 g/kg/day) for five weeks. The animals were divided into 2 groups: one group of 5 rats receiving distilled water and another group of 20 rats receiving ethanol. At the end of the 5 weeks of administration of ethanol, the animals were divided into 4 groups of 5 rats each: one group of hypertensive rats receiving distilled water, another one receiving nifedipine (10 mg/kg), and two groups of hypertensive rats receiving Cyperus rotundus at doses of 100 and 200 mg/kg respectively. The results showed that administration of extracts and nifedipine caused a significant decrease of MAP compared to hypertensive rats and also significantly improved lipid profile and antioxidant status.

Keywords: Anti-hypertensive, Blood Pressure, High Blood Pressure.