Abstract

TETRACYCLINE ANTIBIOTIC TESTING USED IN THE TREATMENT OF THE ACUTE RESPIRATORY INFECTIONS (ARI) CASE AS AN EFFORT TO EVALUATE DRUG QUALITY

Danni Ramdhani*, Sri Agung Fitri Kusuma, Ika Khumairoh, Dede Sediana

ABSTRACT

Objective. Acute respiratory infections (ARI) is an acute inflammation of the upper and lower respiratory tract caused by infection of microorganisms or bacteria, viruses, without or with inflammation of the lung parenchyma. The use of antibiotics is one way to overcome the disease ARI. However, over time many occur resistant to the antibiotic. The purpose of this study was to determine the effectiveness of tetracycline antibiotics to treat respiratory syndrome chemically that is by testing the levels of antibiotic drugs as a quality requirement of a drug. Methods. Drug sample obtained from health center of Tasikmalaya city. The sample is a tetracycline antibiotic used to treat the ARI case. Tests carried out using UV-Visible spectrophotometer instrument, with validation parameters: linearity, precision, accuracy, Limit of Detection (LOD) and Limit of Quantification (LOQ). Result. The test results showed that the levels of levofloxacin antibiotics that are used to meet the requirements that exist in the Indonesian Pharmacopoeia grading 102.76%, and the validation parameters that meet the requirements, koefesisen correlation of 0.9978, accuracy 99.786 %, precision 0.08011%, LOD 1.6264 μg/mL and LOQ 54213 μg/mL.

Keywords: Tetracycline, UV-Visible Spectrophotometer, Validation Parameters, Indonesia Pharmacopoeia.