Abstract

EXPERIMENTAL ANIMAL MODELS FOR GASTROINTESTINAL ULCER DISEASE

Mrunal Patila and Kedar S. Prabhavalkara,*

ABSTRACT

Gastric ulcer is one of the most serious gastrointestinal disease. Ulcers are mainly caused by imbalance between the gastroduodenal mucosal defensive factors versus aggressive factors. In gastric ulcer disease, animal models have helped to understand the basic mechanisms responsible for the formation of gastric ulcers and its treatment. The limited number of animal models for the study of gastric ulcer has hindered the process of research in gastrointestinal disorders. Therefore it is important to review the available literature for animal models of gastric ulcer. Available models include primates, rats, mice, rabbits, cats, guinea pigs, ferrets and pigs. The main aim is to provide scientific information about different animal models to induce gastric ulcers as well as for the screening of antiulcer activity. In this review, we summarize different experimental animal models used in clinical research during past few decades to carry out antiulcerative activity of new agents as well as its underlying mechanisms.

Keywords: Gastric ulcer; animal models; NSAIDs; antiulcerative activity; diethyldithiocarbamate; COX.