Abstract

FORMULATION, EVALUATION AND OPTIMIZATION OF FAST DISINTEGRATING ATENOLOL MALEATE 25 MG. TABLET BY DIRECT COMPRESSION METHOD

Jameel Abbas*, Ansari Yaasir Ahmed, Dr. Malik Tauheed Ahmad, Dr. Sayed Isar Ahmad, Sayyed Mukhim and Mohd. Azharuddin

ABSTRACT

The most common preferred route is oral rout of administration. Today oro-dispersible tablet from novel drug delivery system gain importance from patient. Which is administer to the patient to control the attack of angina or hypertension, but for immediate control, Oro-dispersible tablet is oral solid dosage form in which the tablet gets dispersed in oral cavity in absence of water. Various manufacture are formulated this formulation by various method. The most importance thing in this formulation are masking of taste of drugs. Generally oro-dispersible tablet are prepared by direct compression method. Dry granulation, wet granulation, Spry drying is the various methods for preparation of oro-dispersible tablet. Oro-dispersible tablet generally contains filler, glidant, anti-adherent super disintegrate, sweetener and resins. Evaluation parameter includes hardness, friability, wetting time, moisture uptake, disintegration test, and dissolution test. Wetting time, Disintegration time, and Dissolution test is directly proportional to the hydrophobic ingredient added for lubrication, anti-adherent, Glidant action. These hydrophobic ingredient are Magnesium Stearate. To oppose the action of magnesium stearate, hydrophilic additives are incorporated viz Sodium lauryl sulphate, Cross carmillose sodium, sodium starch glycol ate are added.

Keywords: Oro-dispersible tablet, wetting time, Dissolution test.