Abstract

FORMULATION AND EVALUATION OF ANTIINFLAMATORY & ANALGESIC HERBAL OINTMENT OF PUNICAGRANATUM PEEL

Ghodke Amol D.*, Jain Shirish P., Bhusari Dipak V., Bochare Umesh J., Kothari Chetana R. Bhalke Meena V. and Kochar Pooja P.

ABSTRACT

The present study was aimed to developed formulation on the Antiinflamatory, & Analgesic activity of Punicagranatum peels waste. Non steroidal antiinflamatory drugs (NSAIDs) are associated with too much side effects and adverce drug reactions. Constant used of NSAIDs produces gastrointestinal irritation and another side effects on body organs like liver and kidneys. Antiinflamatory, & Analgesic activity of Punicagranatum peel extract was previously reported on different experimental models. Generally pomegranate peels are waste material obtained from many pomegranate processing industries. These peels consists important polyphenols, flavonoids & β-sitosterol as a active chemical constituents which is useful in the inflammation. Inflamation are associate with pain, readness & swelling. Flavonoids shows antioxidant activity with indirect inhibition of inflammatory markers such as tumor necrosis factor alpha. Analgesic activity of punicagranatum peels are useful in the management of pain. Ointment formulation of punicagranatum peel shows a good result in all the evaluation test parameters such as General appearance, Consistency, pH, Spreadability, Extrudability, Diffusion study, Non irritancy test, & Stability study etc.

Keywords: Punicagranatum, Herbal Ointment, Antiinflamatory, Analgesic, ?-Sitosterol, etc.