Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISSOLING TABLET OF LABETALOL HCL

Gaurav C. Saupure*, Nilesh P. Salunkhe, Sandip A. Tadavi, Sunil P. Pawar

ABSTRACT

Delivery of drug is always been a challenge and is the most important aspect in formulation. Drug are usually delivered via different delivery systems and selection of the system depends on drug solubility, bio available half life, site of action etc. Oral delivery is usually the preferred route of drug administration, and there have been many advances in controlling the release rate of a drug and its bioavailability. Increased patient compliance is important for any Drug delivery system. Many patients do not adhere to a regime of prescribed drugs because of difficulty in administration or the taste of a drug. So it is vital to ensure the convenient administration of a drug. In the present work, fast dissolving tablet of Labetalol Hcl prepared using novel co-proceed superdisntegrants and physical mixtures consisting of avicel pH 102 and Ac-Di-sol in the different ratio and in vice versa. Labetalol Hcl is a drug of choice which is used in treatment of Hypertension and Angina. Drug compatibility with excipients was checked by FRIR studies. After examining the flow properties of the powder blends the results are found to be with in prescribed limits and indicated good flow properties. It was then subjected to tablet compression. All the formulation were subjected to post compression parameters like hardness and friability and they showed good mechanical strength and resistance. From this study, it can be concluded that dissolution rate of Labetalol Hcl FDTs can be enhanced by the use of coprocessed superdisintegrants.

Keywords: Formulation, Development, Labetalol Hcl, FAST Dissolving.