Photo Gallery



News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • MAY 2021 Issue has been successfully launched on 1 May 2021.



Siddique NA, Ahmad S, Mujeeb M*


Introduction and Aim: In present investigation in-vitro and In-vivo antioxidant and nephroprotective activities of aqueous root extract of Delphenium denudatum were evaluated. Materials and Methods: Free radical-scavenging activity of aqueous roots extract was carried out by DPPH HPLC method. The in-vitro nephroprotective study was investigated by GGT assay (γ-glutamyl transpeptidase) method. In-vivo antioxidant and nephroprotective potential of aqueous root extract of Delphenium denudatum (300,600 and 800 mg kg-1) were screened in animal rats model. Oxidative stress and nephrotoxicity was induced by cisplatin (5mg kg-1 bw). Results: Aqueous root extract of Delphenium denudatum showed 83.38% inhibition where as 92.67% inhibition was produced by standard reference (ascorbic acid). The IC50 of root extract was found to be 189.3 where as IC50 61.29 was produced by standard drug mesna (Sodium 2-mercaptoethanesulfonate) in GGT assay. In this study the aqueous root extract of Delphenium denudatum at a dose of (300,600 and 800 mg kg-1) showed significant dose-dependent reduction in the elevated blood urea, uric acid, serum creatinine and normalized the histopathological changes. However, oxidative stress was noticed in renal tissue as evidenced by a significant decrease in glutathione level, superoxide dismutase and catalase activities, also a significant increase in malondialdehyde levels when compared to control group. The animal in the curative regimen showed good response to the aqueous extract at 800 mg kg-1 bw. Conclusion: It is concluded that the aqueous root extract of Delphenium denudatum possesses nephroprotective and antioxidant activity and could offer a promising role in the treatment of renal injury caused by nephrotoxins like cisplatin.

Keywords: Delphenium denudatum, Nephroprotective activity, GGT, Cisplatin, Phenolics compounds, Flavonoid compounds

[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More