Abstract

FORMULATION AND EVALUATION OF SUBLINGUAL TABLET CONTAINING RIZATRIPTAN BENZOATE

Vaibhav K. Patil*, Ganesh N. Patil, Sulbha G. Patil and Dr. S. P. Pawar

ABSTRACT

Rizatriptan benzoate is a potent and selective 5-HTIB/ID receptor agonist and is effective for the treatment of acute migraine. Sublingual formulation has the advantage of offering fast relief from migraine due to faster drug delivery. The present study involves the formulation and evaluation of fast disintegrating sublingual tablets of Rizatriptan benzoate to produce intended effects. The sublingual Rizatriptan benzoate tablets were prepared by the method of direct compression. The compatibility studies of drug and excipients were performed by FTIR spectroscopy. After examining the flow properties of the powder blends, the results are found to be within prescribed limits and indicated good flowing property, it was then subjected to tablet compression. The powder flow properties of all formulations were evaluated for diameter, thickness, weight variation, hardness, friability, wetting time, drug content, as well as in vitro release and were found to be satisfactory. The superdisintegrants used were sodium starch glyconate and cross povidone. An optimized tablet formulation i.e. F3 was found which provided short wetting time of 19.15 sec, in-vitro disintegration time of 13sec which facilitates its faster disintegration and higher drug content of 99.37%, the best in-vitro drug release was found to be in formulation F3 i.e. 99.27% during the end of 15min.

Keywords: Sublingual tablets, Rizatriptan benzoate, Crossprovidone, Avicel pH 102.