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  • WJPPS MAY ISSUE PUBLISHED
  • MAY 2021 Issue has been successfully launched on 1 May 2021.

Abstract

SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NEW 4{[(ARYL)METHYLENE]AMINO}-2-METHYL-5,6-SUBSTITUTED THIENO[2,3-D]PYRIMIDINES

K. Naresh*, Y. Rajeshwar and K. N. Jayaveera

ABSTRACT

In continuation to our earlier reported work on the synthesis of novel fused thieno[2,3-d]pyrimidine derivatives, we synthesized two new series of 4{[(aryl)methylene]amino}-2-methyl-5,6-substituted thieno[2,3-d]pyrimidines by the condensation of 4-amino-2,5,6– substituted theino[2,3-d]pyrimidines (ANP and ANH) with nine aromatic aldehydes. The synthesized compounds were characterized by physical and spectral data. The compounds were further evaluated for the antibacterial and antifungal activity employing disc diffusion method.

Keywords: thieno[2,3-d]pyrimidines, antibacterial, thiophene, aromatic aldehydes


[Full Text Article]

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