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Abstract

METHOD DEVELOPMENT AND VALIDATIONFOR SIMULTANEOUS ASSESSMENT OF PARACETAMOL AND NAPROXEN IN MIXEDTABLET DOSAGE FORM BY RP-UPLC

K. Kanaka Parvathi*, Vijay Nagarjan, Shantha Arcot

ABSTRACT

The present manuscript describes an advancement design and corroboration for simultaneous assessment of Naproxen (NAP) and Paracetamol (PAR) in merged tablet dosage form by UPLC. The column employed in this determination was C18 thermo fisher (50mm x 4.6 mm x 3μm), mobile phase comprising0.4% w/v ammonium acetate buffer: methanol: acetonitrile in the ratio of 40:40:20 v/v/v. the flow rate and injection volume were 0.2μL-1 and 1 μL respectively. The detection wave length was set at 271nm, the retention time was about 1.9 minutes and 3 minutes for PAR and NAPof a total run time of 5 minutes, linearity of the method was linearover the range of 38 to 57μg/ml for PAR and 64 to 96μg/ml of NAP respectively with a correlation of 0.9999 and 0.9997for NAP and PAR simultaneously,thus assessment for PAR and NAP through this method was fast, simple, elegant and less time consuming method.

Keywords: Naproxen, Paracetamol RP-UPLC, Method validation.


[Full Text Article]

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