Abstract

PHARMACOKINETICS AND TISSUE RESIDUES OF MARBOCYL IN NORMAL AND AEROMONAS HYDROPHILIA INFECTED CATFISH (CLARIAS LAZERA)

El-Sayed M. G. A., Enas A. H. Farag and Shimaa F. Elzoghby*

ABSTRACT

The pharmacokinetics of marbocyl were studied following intravenous and intramuscular (single and repeated) administrations. Following a single intravenous injection of 10 mg/kg body weight of marbocyl in normal catfish (Clarias Lazera), serum concentration-time curve was best described by two compartments open model with elimination half-life (t0.5β), volume of distribution (Vdss) and total body clearance (CLtot) of 7.018 hours, 783.230 ml/kg and 91.819 ml/kg/min, respectively. Following a single intramuscular administration of 10 mg marbocyl /kg body weight in normal catfish (Clarias Lazera), the peak serum concentration (Cmax) was 8.721 μg/ml, achieved at a maximum time (Tmax) of 2.134 hours. The mean systemic bioavailability was 68.34%. The serum concentrations of marbocyl following repeated intramuscular administration of 10 mg/kg body weight once daily for five consecutive days in normal and experimentally Aeromonas hydrophilia infected catfish (Clarias Lazera) showed a lower significant value recorded in experimentally Aeromonas hydrophilia infected catfish (Clarias Lazera) than in normal ones. Marbocyl showed accumulative behavior in serum of fish. Results of this study indicated that marbocyl was useful for treatment of Aeromonas hydrophilia infections in fish. Marbocyl was assayed in serum, liver, kidney, dorsal muscle, abdominal muscle and skin after 24, 48, 72, 96 and 120 hours from the last daily dose of 10mg marbocyl /Kg body weight for five days.

Keywords: Aeromonas hydrophilia infected catfish (Clarias Lazera).