Abstract

DEVELOPMENT AND EVALUATION OF OCCULAR INSITU GEL OF OFLOXACIN

Dillip Ku Jena*, S. B. Bhanja, Bijayalaxmi Sabar, Uttarabali Sabar, B. B. Panigrahi, Nilima Shukla

ABSTRACT

Ofloxacin is a fluorinated 4-quinolone antibiotic which is used in the treatment of ophthalmic ailments like infections, inflammations, conjunctivitis, iritis, corneal ulcer etc. Commercially, ofloxacin eye drop solution is available and it is quite easy for the administration. However, the product has drawback of poor bioavailability due to several factors such as tear production, nonproductive absorption, transient residence time, and impermeability of corneal epithelium. In order to improve the bioavailability, residence time and longer duration of action, an attempt was made to formulate in-situ ophthalmic gel of Ofloxacin. In present study Carbopol 934P and Sodium alginate were used as polymers. Carbopol 934P was used as a pH sensitive polymer. The prepared formulations were evaluated for pH, viscosity, clarity, drug content, gelling capacity, In-vitro diffusion study and stability studies. The pH, drug content and viscosity of optimized formulation, F3 was found to be 6.56, 97.28% and 2341 cps respectively. The In-vitro drug release study of optimized formulation, F3 was found to be 96.58% at the end of 8 hrs The developed formulation can be used as an in-situ gelling vehicle to enhance ocular bioavailability and helped in the reduction in the frequency of instillation thereby resulting in better patient compliance.

Keywords: Ofloxacin, Gelling capacity, Viscosity, In vitro diffusion studies.