Abstract

SYNTHESIS OF NOVEL 1,2,4-TRIAZOLES AND THEIR SCHIFF BASE DERIVATIVES AND EVALUATING THEIR ANTIMICROBIAL ACTIVITY

* Jigisha A Modi  , K R Desai and Snehal R Lokhandwala

ABSTRACT

An efficient synthesis was carried out for synthesizing novel schiff base derivatives of 1,2,4-triazoles in a good yield from the reaction of 4-amino-5-(3-bromo-4-methoxyphenyl)-4,5-dihydro-3H-1,2,4-triazole- 3-thiol with substituted aldehydes in methanol in presence of conc. HCl. The structures of these compounds were confirmed by IR, 1H NMR & 13C spectral analysis. The compounds were assayed by the disk diffusion method and broth dilution technique against B.Subtilis (Gram +ve) (ATCC-6633),E.Coli (Gram -ve) (ATCC-6538) & C.Albicans (ATCC-64550).

Keywords: Triazole, Schiff base, Minimum Inhibitory Concentration (MIC).