Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE FLOATING PELLETS OF ONDANSETRON HYDROCLORIDE

Sanketh T., P. Ashok Kumar* and Suresh V. Kulkarni.

ABSTRACT

The aim of the present study was design and develop model sustained release pellets formulations for Ondansetron HCL. Ondansetron hydrochloride at different drug to polymer ratios were prepared by extrusion and spheronization technique. The influence of the proportion of the polymer on the release rate of the drug from the pellets was studied. The in-vitro release studies of pellets were carried out in 0.1N HCL for 6 hours. The studies indicated that the drug release can be modulated by varying the concentration of the polymer. Pellets were prepared and evaluated for various properties, shows satisfactory results. Formulation was optimized on the basis of acceptable pellet properties and in-vitro drug release. The resulting formulation produced robust pellets with acceptable drug content and low friability. Kinetic modeling of in-vitro dissolution profiles revealed Quasi-Fickian diffusion mechanism, which was only dependent on the type and amount of polymer used. The drug release of the optimized formulation (F1) follows Zero order kinetics. The compatibility studies were performed by using FTIR and DSC which reveals that there is no interaction between the drug and the polymer/excipients mixture.

Keywords: Sustained release, Ethylcellulose, HPMC, Pellets, Ondansetron hydrochloride