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Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF IN SITU FLOATING GEL OF DOMPERIDONE

Nilesh P. Salunkhe*, Dipak A. Patil, Sandip A. Tadavi and Sunil P. Pawar

ABSTRACT

The present investigation deals with the formulation development and evaluation of floating in situ gel based gastroretentive drug delivery system of Domperidone. Sodium alginate was used as a polymer and CaCo3 was used as a cross linking agent. In situ gel forming polymeric formulations are in solution form before administration, but once administered undergoes gelation in situ to form a gel, in response to temperature or pH. Oral tablet administration to patients is a significant problem and has become the object of public attention. The demand for liquid dosage forms that can be easily ingested is particularly strong in the pediatrics and geriatric markets. The objective of this study was to develop a novel in situ gel system for sustained drug delivery using natural and ionic cross linking biodegradable polymer. This system includes polymers that exhibit sol-to-gel phase transition due to change in specific physico-chemical parameter i.e, biological pH. Prepared formulations (solutions) were evaluated for pH, Viscosity, In vitro floating time, In vitro gelation, swelling index, Drug content and cumulative amount of drug release. From the desired set of experiments, it was evident that formulation containing sodium alginate and xanthan gum can control the release of drug for longer duration(12hours). The FTIR study has shown that there is a good compatibility between the drug and polymer. The in situ gel exhibited the optimum pH, viscosity, swelling index in vitro floating ability, in vitro gelling capacity, drug content and the amount of drug release.

Keywords: Floating In situ Gel, Domperidone, Sodium alginate, Xanthan gum, HPMC K15M.


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