Abstract

FORMULATION AND EVALUATION OF CEFDINIR NANOGEL

*Rathore Shrikant, *Khan Mohd. Faarooq and Dr. Sharma Vimukhta

ABSTRACT

Hydrogel nanoparticles (also referred as nanogels) have received considerable attention as drug delivery systems, mainly because they combine the advantages resulting from their small dimension (improved bioavailability, large surface area for multivalent bioconjugation, targeted delivery of drug) with hydrophilic cefdinir is an advanced third generation, broad-spectrum cephalosporin antimicrobial agent that has been approved for the treatment of community-acquired pneumonia, acute bacterial exacerbations of chronic bronchitis, acute maxillary sinusitis, and pharyngitis/tonsillitis. The present research work was aim to develop the nanogel of k-carrageenan containing poorly water soluble drug. That fulfills the behaviour of k-carrageenan in nanogel form, the effect of k-carrageenan in solubility improvement of poorly water soluble drug, study the effect of different surfactant type and different surfactant concentration on particle size of k-carrageenan nanogel. Characterisation of cefdinir was done by organoleptic properties, melting point, spectrophotometric analysis, FTIR spectroscopy, preformulation study was done by preparation of calibration curve and solubility studies then nanogel was prepared using cefdinir cyclohexane and n-butanol mixture aqueous phase and different molar ratio of water to surfactant, different type of surfactant, cefdinir nanogel was characterised by particle size, zeta potential, drug entrapment and drug release. it may be concluded that formulation of cefdinir prepared with solubility, dissolution rate and bioavailability. The results obtained may be considered as tools for the manufacturer of standard formulation with great efficacy.

Keywords: Hydrogel, Nanogel, Nanoparticles, Cefdinir, Carrageenan.