Abstract

DEVELOPMENT AND EVALUATION OF FLOATING SUSTAINED RELEASE BILAYER TABLETS CONTAINING NIMODIPINE

Chandan H. G., P. Ashok Kumar*, Mancy S. P. and Suresh V. Kulkarni

ABSTRACT

Bilayer floating tablets of Nimodipine were developed by direct compression method. Immediate release layer contains 30mg of drug and super disintegrate sodium starch glycolate, serves the purpose of loading dose. Sustained release layer contained HPMC K4M, natural polymers like xanthan gum, guar gum, locust bean gum and karaya gum released the drug for 12 hours. Sodium bicarbonate and citric acid are used to produce effervescence. Floating lag time of optimised tablet is 92 seconds, whereas floating duration is more than 12 hrs. FTIR results exposed that there was no interaction between drug, polymers and excipients used in formulation. The pre and post compression parameters of developed tablet are acceptable. In this study it was confirmed that the formulations containing HPMC K4M, have shown better floating properties and finally the formulation containing a combination of HPMC K4M and Xanthan Gum in 3:1 ratio, have shown slower in-vitro drug release properties. The release kinetics of optimised formulation prepared with the combination of HPMC K4M and Xanthan gum followed zero order kinetics.

Keywords: Floating bilayer tablet, Nimodipine, HPMC K 4M, Xanthan gum, FTIR.