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Abstract

DEVELOPMENT OF NOVEL METHOD FOR ESTIMATION OF METFOMIN HCL, GLIMEPIRIDE AND VOGLIBOSE IN MULTI INGREDIENT DOSAGE FORM BY DERIVATIVE SPECTROSCOPY

Ashwini S. Deshpande*, Nilesh Ahire, Shashikant B. Bagade, and Shirish S. Deshpande

ABSTRACT

In the present study derivative spectroscopy has been developed for the estimation of anti diabetic drugs, Metformin HCl, Glimepiride and Voglibose in multi ingredient tablet formulation. In this study a second order derivative spectroscopy method was used for estimation of anti diabetic drugs using zero- crossing method. Method І was based on simultaneous equation method for estimation of GLM and VOG; the absorbances were measured at 246nm, 234nm respectively, being the zero absorbance points for metformin HCl. Method ІІ was based on calibration curve method for estimation of Metformin hydrochloride absorbance measured at 256nm. For both the methods second order derivative spectra was generated between 400-200 nm. There is no any method reported for the estimation of Metformin hydrochloride, Glimepiride and Voglibose in multi ingredient tablet dosage form. Hence a simple, sensitive, reliable and rapid spectroscopic method has been developed for the determination of mentioned drugs in multi ingredient tablet dosage form. All these drugs obey Beer’s law in the concentration range between 20-100μg/ml, 20-80μg/ml, and 5-60μg/ml respectively, when converted to second order derivative. The method was validated as per the ICH criteria for method validation in terms of accuracy, precision, linearity, specificity, and robustness. This method could be useful for routing quality control analysis of mentioned drugs and their dosage forms.

Keywords: Metformin hydrochloride, Glimepiride and Voglibose, Derivative spectroscopy.


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