Abstract

HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITIES 0F CARICA PAPAYA FRUITS IN STREPTOZOTOCIN INDUCED DIABETIC MICE

Md. Monirul Islam, Ariful Islam, Md. Wasim Bari, Md. Ismail Hossain, Md. Abdul Matin, A.B.M. Khalid Hossain Siddique and Mohammad Amirul Islam*

ABSTRACT

Diabetes mellitus (DM) is a systemic metabolic disorders with several major health complications affecting both the quality and the length of life. The purpose of this study is to appraise the antidiabetic and antihyperlipidemic activities of the Carica papaya fruits. Diabetes was induced in overnight fasted mice by a single intraperitoneal injection of Streptozotocin (60 mg/kg body weight) in a 0.1 M sodium citrate buffer (pH 4.5). The animals were divided into five groups with five animals in each and treated with methanolic extract of C. papaya unripe fruits at dose 100 mg/kg and 200 mg/kg body weight respectively. The results showed that C. papaya unripe fruits decrease blood glucose level significantly (p<0.001 to p<0.01) and also regulated parameters of lipid profile levels (TG, TC, LDL, VLDL, and HDL) significantly (p<0.001 to p<0.01) in experimental model of diabetes mellitus. The levels of serum SGPT, SGOT and CRP were also adjusted to the normal level notably (p<0.001 to p<0.01) by the oral administration of methanolic extract of C. papaya unripe fruits (MCUF). The results obtained from this study indicate that the methanolic extract of Carica papaya unripe fruits contains bioactive substances with hypoglycemic potency.

Keywords: Diabetes, Antidiabetic, Carica Papaya, Lipid Profile.