Abstract

REVIEW ON ECONAZOLE

Neha R. Patil*, Vipul H. Jain and Sunil P. Pawar

ABSTRACT

Econazole is a synthetic imidazole active against fungi and Gram-positive bacteria. Econazole is used to treat skin infections such as athlete's foot, jock itch, and ringworm. An imidazole derivative that is commonly used as a topical antifungal agent. Econazole has low aqueous solubility. It was patented in 1968 and approved for medical use in 1974.Molecular Weight of econazoleis 381.684gm/mol. Ecostatin (Bristol-Myers Squibb) / Gyno-Pevaryl (Janssen) / Ifenec (Italfarmaco) / Palavale (Otsuka Pharmaceutical) / Pevaryl (Janssen) are marked brands of econazole. Econazole is solid in nature. Melting point of econazole is 162℃.Econazole compromises the integrity of fungal cell wall through inhibiting 14-alpha demethylase which leads to increase permeability of fungal cell wall and cause leakage of cellular components of fungi. In this presentreview provides account on drug profile and information ofeconazole.

Keywords: Econazole, Antimycotic, Imidazol.