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B. P. Alta*, M. Bhavya, M. Vinay Kumar, G. Sravanthi and E. Ganesh


Rizatriptan a 5-HT 1B and 5-HT 1D antagonist which is an antimigraine water soluble drug belongs to class III of BCS classification of drugs. The present study was aimed to formulate and evaluate mouth dissolving films of drug using hydroxyl propyl methyl cellulose. Hydroxyl propyl methyl cellulose is the polymer used as film forming agent and propylene glycol used as plasticizer. Mouth dissolving films are meant to be dissolved in saliva and remain in oral cavity until swallowed. The films are prepared by solvent-casting method and characterized by UV studies. The suitable plasticizer concentrations were selected on the basis of flexibility, folding endurance and stickiness of the film. The other excipients like Citric acid and aspartame are used in the preparation as mouth dissolving agent and sweetner. Films were evaluated for various tests like thickness, folding endurance, drug content, disintegrating time, weight variation, in vitro dissolution time. The optimized formulation F4 showed satisfactory mechanical properties, disintegration time less than 1 mint and percentage drug release was found to be 98.62% per 2cm2. From the above data, it can be concluded that HPMC E15 and Propylene Glycol 400 polymers was successfully used to formulate rizatriptan mouth fast dissolving films by Solvent-casting method.

Keywords: Rizatriptan, HPMC E15, Propylene Glycol 400, Solvent-casting method, Mouth dissolving films.

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