Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS OCTOBER ISSUE PUBLISHED
  • OCTOBER 2020 Issue has been successfully launched on 1 October 2020.

Abstract

FORMULATION AND EVALUATION OF MOUTH DISSOLVING FILM OF DESIPRAMINE HCL FOR THE MANAGEMENT OF DIPRESSION CONDITION

Azam Z. Shaikh*, Sandip A. Tadavi, Manashi P. Valavi, Sunil P. Pawar and Prof. H. D. Mahajan

ABSTRACT

The present investigation was undertaken with an objective of formulating mouth dissolving films (MDFs) of DESIPRAMINE HCL to enhance convenience and compliance of the elderly and pediatric patients for better therapeutic efficacy. DESIPRAMINE HCL is, Tricyclic antidepressant used in the management of depression condition. The film prepared with Desipramine HCL is enhance the bioavailability, and is very convenient for administration, without the problem of swallowing and using water. Materials and Methods: The films of DESIPRAMINE HCL were prepared by using polymers such as hydroxypropyl methylcellulose (HPMC) and there different grades like E15 as a single polymer by a solvent casting method. They were evaluated for physical characteristics such as uniformity of weight, thickness, folding endurance, drug content uniformity, surface pH, percentage elongation, and tensile strength, and gave satisfactory results. The formulations were subjected to disintegration, in vitro drug release tests. Results: A marked increase in the dissolution rate was exhibited by fast-dissolving films of DESIPRAMINE HCL containing HPMC E15 as a polymer, when compared to conventional tablets. Conclusions: Fast dissolving films of DESIPRAMINE HCL can be considered suitable for clinical use in the management of depression condition, where a quicker onset of action for a dosage form is desirable along with the convenience of administration.

Keywords: Desipramine HCL, quick release, films, Innovative drug delivery, patented technologies, Disintegrating systems, Dosage forms.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More