Abstract

CHALLENGES IN DEVELOPMENT OF COLON DRUG DELIVERY SYSTEM WITH RESPECT TO DISSOLUTION STUDIES

Anchal Gaur, Dr. Ashu Mittal*, Debaprasad Ghosh and Dr. Jagannath Sahoo

ABSTRACT

Colon drug delivery has gained increased importance not only for the treatment of local diseases associated with colon but also for its potential for delivery of proteins and therapeutic peptides. Local delivery allows topical treatment of inflammatory bowel disease, Crohn‟s disease, Ulcerative colitis. However, treatment can be made effective if drugs can be targeted directly into colon, thereby reducing systemic side effects. New technologies have been developed for colon targeting and to overcome the problem of previous methods. Oral dosage forms are the most preferred delivery route for colon- specific delivery due to their convenience. A broad range of in vitro systems is available, from static monocompartmental to dynamic multicompartmental models. However, these models require a compromise between technological complexity and biological significance. Further efforts and technological innovations are still needed to improve in vitro models and meet growing demands in the areas of health. This review highlights about the challenges in development of colon drug delivery system with respect to dissolution studies. Oral delivery of drugs in the colon is valuable in the treatment of diseases of colon where by high local concentration can be achieved while minimizing side effects.

Keywords: Colon targeted drug delivery, Dissolution, Colon products, Colon technology.