Abstract

FORMULATION & EVALUATION OF SOLID DISPERSION OF ETORICOXIB FOR SOLUBILITY ENHANCEMENT BY USING ?- CYCLODEXTRIN

Rajnandini Patidar* and Dr. Shikha Agrawal

ABSTRACT

Etoricoxib is a large lipophilic molecule that is practically insoluble in water and exhibit an exceesively slow dissolution rate in making a class II compound in biopharmaceutics classification system. This study is formulate solid dispersion of etoricoxib using hydrophilic carriers in different ratio and determine effect on solubility of drug. Solid dispersion of etoricoxib was prepared using PVP K 30, PEG 4000 and β-cyclodextrin as carriers in different ratio of by employing solvent evaporation method. The solid dispersion was evaluated for solubility studies, drug content, FTIR studies, DSC studies, dissolution studies. The saturated solubility studies and In-vitro dissolution studies as observes that the increase in solubility of drug and enhanced dissolution rate in solid dispersion compared to pure drug. The Formulation containing 1:1 ratio of drug: β-cyclodextrin is considered as best formulation as it has shown highest drug release in short time. Our studies showed that the solubility of the drug can be significantly enhanced with solid dispersion of the polymers. With increase in the carrier content there is increase in the solubility resulting in enhanced dissolution rate.

Keywords: Etoricoxib, Hydrophilic carriers, Solubility enhancement, Solvent evaporation method.