Abstract

DESIGN, DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE TABLETS OF PENTOXIFYLLINE

Reshma R. Patil. *, Pranita T.Gaikwad, M.A. Bhutkar

ABSTRACT

Purpose: The objective of this study is to test new formulations, regarding modified release tablets containing pentoxifylline, obtained by technological modulation of the drug release from tablets. we investigate the effect of combination of hydrophilic and hydrophobic wax polymers. Method: We prepared sustained release granules consisting of a hydrophobic wax and granules consisting of a hydrophilic matrix base using the ordinary granulation method, unlike the film coating method using organic solvents and mixed them at a particular ratio to control the release rate and obtained sustained release tablets of pentoxifylline with a satisfactorily reproducible release rate. Result and conclusion: The drug release from various tablets was analyzed according to release kinetics theories. For the tablet formulation no. 6, the value of exponent (n) of the apparent diffusion mechanism calculated by the Korsmeyer–Peppas model was unlikely to be affected by the paddle rotation speed, and was about 0.659. These results suggested that the drug release mechanism of tablet prepared by mixture of both hydrophilic and hydrophobic wax polymers was not easily changed by physical agitation and probably even by peristaltic movement in the gastrointestinal tract.

Keywords: Pentoxifylline, water soluble, Matrix Tablet, hydrophilic, hydrophobic wax polymers.