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Abstract

DERIVATIVE SPECTROPHOTOMETRIC ESTIMATION OF NEVIRAPINE IN PHARMACEUTICAL DOSAGE FORM

Yogesh S. Thorat, Parikshit D. Shirure*, Naushad N. Mirza and Avinash H. Hosmani

ABSTRACT

The first derivative spectrophotometric method in methanol have been developed for the determination of Nevirapine in bulk drug and its pharmaceutical formulations. Nevirapine exhibits absorption maxima at 295 nm. In the first derivative spectra of Nevirapine, the amplitude of positive maxima was measured at 291nm. Linearity in the concentration range was found to be 5-30μg/ml. The results of analysis have been validated statistically and also by recovery studies. The method were found to be simple economical accurate and reproducible and can be adopted in routine analysis of Nevirapine in bulk drug and Pharmaceutical dosage form.

Keywords: Nevirapine, First Derivative Spectrophotometry, NRTI etc.


[Full Text Article]

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