Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF LEVETIRACETAM BY FORCED DEGRADATION STUDIES

Apurva N. Gaikwad*, Manjusha N. Dole and Akshay G. Ramphale

ABSTRACT

The present work describe development and validation of precise, accurate, sensitive and stability indicating high performance liquid chromatographic method for analysis of Levetiracetam in bulk and Pharmaceutical dosage form. The mobile phase used for separation is Methanol:Water(60:40v/v) using Hi Q sil C-18 (250 mm × 4.6 mm, 5 μm) column with the flow rate of 0.8ml/min. The detection was done at 215nm using PDA detector. The retention time of Levetiracetam was found to be 5.11 ±0.5min. Levetiracetam was subjected to stress conditions including acidic, alkaline, oxidation, Neutral hydrolysis, Photolytic stress conditions. This method was applied to pharmaceutical dosage form. Linearity was found to be 10-50μg/ml with significantly higher value of correlation coefficient (r2=0.9994). The method was validated for linearity, accuracy, precision, robustness and recovery. The limit of detection and limit of quantitation were found to be 0.226 μg/ml and 0.68μg/ml respectively.

Keywords: Levetiracetam, RP-HPLC, Antiepileptic, Forced degradation Validation.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More