Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS OCTOBER ISSUE PUBLISHED
  • OCTOBER 2020 Issue has been successfully launched on 1 October 2020.

Abstract

ANALYTICAL METHOD DEVELOPMENT & VALIDATION OF A METHOD FOR THE QUANTITATION STUDIES OF PRAZIQUANTEL AND PYRANTELPAMOATE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY USING RP-HPLC

Rajendra G. Shete, Dr. N. S. Dighe* and K.V. Dhamak

ABSTRACT

The Present manuscript describes a new simple, specific, precise and accurate reverse phase high performance liquid chromatography method for the RP-HPLC for quantitation studies for praziquantel and pyrantel pamoate in bulk dosage form. The quantitation studies were carried out by using C18 (250 x4.6 mm) colum with mobile phase contaning methanol: water in thre ratio of80:20 buffer PH was maintained at 4.5 adjusted with 0.01m orthophosphoric acid, which is pumped at a flow rate of 0.8ml/min. For UV detection was monitored at 217nm. The peaks obtained were sharp with retention time of praziquantel and pyrantel pamoate. 5.0 min and 6.59 min respectively. The Calibration Curves were linear (R2=0.999) over the concentration from 5-10ml for praziquantel and pyrantel pamoate. The percentage recoveries of praziquantel and pyrantel pamoate were found to be in the range of 98.06 and 99.98 percent respectively. The proposed method was validated and successfully applied to the quantitation studies of praziquantel and pyrantel pamoate in combined bulk dosage forms. The Calibration Curves were linear (R2=0.999) over the concentration from 5-10 ugml for praziquantel and pyrantel pamoate respectovely. The percentage recoveries of praziquantel and pyrantel pamoate were found to be in the range of 98.06 and 99.98 percent respectively. The proposed method was validated and successfully applied to the quantitation studies of Praziquantel and Pyrantelpamoate in combined bulk dosage form respectively.

Keywords: Praziquantel, Pyrantel pamoate, Quantitation Studies, RP-HPLC, UV Spectroscopy.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More