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Abstract

DEVELOPMENT AND VALIDATION OF RP-HPLC ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF TOPIRAMATE AND PHENYTOIN IN PURE AND ITS PHARMACEUTICAL DOSAGE FORMS

Sagar S. Yenare*, Prof. Jyoti B. Wadekar and Prof. Sandhya R. Lanke

ABSTRACT

Concurrent method was introduced that single analytical which shows simultaneous estimation of individual drug are very competitive task. A simple, Rapid, Accurated, RP_ HPLC method developed for estimation of Phenytoin and Topiramate in pharmaceutical dosage forms.Phenyl column are should be used flow rate shows 1ml/min should be detect at 254nm. The mobile phase was selected for this Acetonitrile; 50mM sodium dihydrogen phosphate (NaH2PO4) that containing 2%v/v trietylamine.pH-2.8 in an ratio 50;50 then flow rate 1.0mL.Run timeshould be taking 10 min.Topiramate and Phenytoin were shows retention time is 3.57 min and 5.17 min. that all Specificity, linearity, Accuracy in accordance with ICH Guidelines. Simultaneous analysis of two drug in pharmaceutical Dosage forms.

Keywords: Topiramate, Phenytoin, Analytical Method Development, UV-HPLC, Validation.


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