Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF PHENYTOIN BULK AND PHARMAEUTICAL DOSAGE FORM.

Sagar S. Yenare*, J. B. Wadekar, M. S. Tare and C. G. Dhaygude

ABSTRACT

Current study is conducted to progress easy UV spectrophotometric technique to Estimation Phenytoin in Pharmacuetical dosage form. The Absorbance solution was prepare by weighing 100 mg of Phenytoin in 100ml methanol in Volumetric flask. All dilution were prepared as per procedure and this will scanned at 247 nm. The Linearityt found in concentration range of 1-5 μg/ml the correlatioin coeifficient was 0.997. The line Regession Equation was found to be Y=0.315X-0.038.The validated method for linearty, accuracy, precision, LOD, LOQ, and Robustness ruggedness. The LOD and LOQ for estimation of phenytoin was found to be 0.015 (μg/ml) and 0.030μg/ml,the percentage recoveryof phenytoin was found tobe in range of 100.25±0.070-100.60±0.045. The developmed Method is also useful for quality control of both bulk production as well as Pharma Dosage Froms.

Keywords: Phenytoin, UVspectroscopy, Method Validation ICH Guidelines.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More