Abstract

FORMULATION OF PRONIOSOME ENCAPSULATED BUDESONIDE FOR PULMONARY DELIVERY SYSTEM

Pradeepa N.* and S. Parthiban

ABSTRACT

Among the various approaches available to enhance the delivery of drugs, site specific pulmonary delivery of Proniosomal encapsulated anti asthmatic drug delivery system in the form of dry power inhalation is an attractive concept that has the ability to control the rate of drug clearance. Budesonide is a corticosteroid used in the prophylactic management of asthma. The present investigation was aimed to prepare proniosome entrapped with Budesonide for a dry powder inhaler formulation. Maltodextrin has been used as carriers for the preparation of proniosome by slurry method. FTIR study showed no significant interaction between drug and excipients. Average particle was found to formulation maximum number of particles were in the range of 208.1 to 237.4 nm. Percentage cumulative drug release was higher in F1 formulation compared to other formulation while entrapment efficiency was more in F4 formulation compare to other formulation. The effect of parameters have been studied by using 2 x 2 factorial design using QI macros R DOE software.

Keywords: Proniosome, maltodextrin, Budesonide.