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Abstract

IDENTIFICATION AND ASSESSMENT OF DRUG-DRUG INTERACTIONS IN A TERTIARY CARE TEACHING HOSPITAL

Merin Titus*, Shana Bency Mathew, Sruthi Syam and Steffi Sandra Jose

ABSTRACT

Objective: The objective of the study is to evaluate the drug interactions as well as antibiotic associated drug interactions among patients in a tertiary care teaching hospital. Materials and Methods: A prospective observational review of the antibiotic prescription was carried out in the medicine department of a tertiary care teaching hospital. 128 case records of patients were identified and evaluated for drug interactions over a period of 6 months. Results: Total of 128 prescriptions were collected. Majority of patients (35.16%) were in the age group of 40-60 yrs. Male patients (64.85%) were more, than female patients (35.15%). A total 279 drug-drug interactions were found, of which 51(18.28%) interactions were major, 158(56.63%) interactions were moderate and 70(25.09%) interactions were minor. Among 34 antibiotic-antibiotic interactions 4(11.76%) were major, 29(85.30%) were moderate and 1(2.94%) was minor. A total of 79 antibiotic and associated drug interactions were found, of which 35(44.30%) were major, 13(16.46%) were moderate, 31(39.24%) were minor. Conclusion: Prescriptions were analysed and drug interactions were identified. Out of 279 drug interactions, the most commonly found drug interactions were moderate (56.63%). Among this 34 were antibiotic-antibiotic interactions and 79 were antibiotic and associated drug interactions.

Keywords: Drug Interactions, Antibiotics, Associated drugs.


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