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Abstract

DEVELOPMENT CHARACTERIZATION AND EVALUATION OF SCLEROGLUCAN BASED MOUTH DISSOLVING FILM

Sachin Devidas Rede*, Sanjay Ravindra Chaudhari, Rohan Patekar, Heena Choudhary

ABSTRACT

Mouth dissolving film is a dosage form, which when placed in the oral cavity will rapidly disintegrate and dissolve to release the medication for oral mucosal absorption or allow for the gastrointestinal absorption to be achieved when swallowed. Flurbiprofen is a low dose non-steroidal anti-inflammatory agent with antipyretic and analgesic activity. A mouth dissolving film would improvise relief of pain by avoiding its hepatic first pass metabolism. This study investigates the use of scleroglucan as the film forming agent for the flurbiprofen mouth dissolving film. Effect of film former and plasticizer was studied by statistical method. Eventually formulation with desirable disintegration time was optimized as the one containing 40%w/w of scleroglucan and 6%w/w of glycerol. The overall result suggests that scleroglucan based mouth dissolving film of flurbiprofen can be conveniently administered orally.

Keywords: Scleroglucan, flurbiprofen, Oral film, Plasticizer.


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