Abstract

A BRIEF REVIEW ON ITRACONAZOLE AND TURBINAFINE

Prachi R. Chaudhari*, Dr. J. K. Patil, V. H. Jain and Dr. S. P. Pawar

ABSTRACT

Itraconazole has broader spectrum of activity. Itraconazole is over 99% protein bound and has virtually no penetration into cerebrospinal fluid. Terbinafine, sold under the brand name Lamisil, among others is an antifungal medication used to treat pityriasis versicolor, fungal nail infection, and ringworm including jock itch and athlete’s foot. Terbinafine is increasingly used in combination with itraconazole antifungal to treat resistant or refractory mycoses due to synergistic in vitro antifungal activity. Due to its broad antifungal spectrum, interest in terbinafine has expanded to include its use in range of cutaneous and subcutaneous mycosis, such as sporotrycosis. As well as in combination with itraconazole to treat resistant or refreactory invasive fungal infection. :- terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase(squalene 2,3 – epoxidase) an enzyme that is part of the fungal cell wall synthesis pathway. Itraconazole inhibit fungal cytochrome P450 3A dependent enzyme decreases ergosterol synthesis and inhibits cell membrane formation.

Keywords: : Itraconazole, terbinafine, onychomycosis, Lamisil, sporonax.