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  • APRIL 2021 Issue has been successfully launched on 1 April 2021.

Abstract

DESIGNING AND IN-VITRO ANTIBACTERIAL ACTIVITY OF NEW BENZOTRIAZOLE COMPOUNDS

Sridevi Chigurupati*, Ravichandran Veerasamy, Appal Raju Nemala,Abhinayani Gowlikar, Kah Seng Lee

ABSTRACT

A series of new benzotriazole compounds (3A-3F) have been synthesized by the reaction of benzotriazole with chloroacetone in the presence of dry acetone and anhydrous Potassium carbonate, the acetylated compound is then converted into chalcones (2A-2F) by aldol condensation with different aromatic aldehydes. The formed chalcones were then treated with benzoic acid hydrazide and converted into corresponding benzotriazolo pyrazolines. The synthesized compounds were screened for their in-vitro antibacterial activity by cup plate method. It can be inferred from the results that the newly synthesized compounds possessing electron withdrawing groups at the aldehydic phenyl ring exhibits better antibacterial activity.

Keywords: benzotriazole, chalcone, pyrazole, antibacterial activity.


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