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  • OCTOBER 2020 Issue has been successfully launched on 1 October 2020.



Kencha Swathi* and Dr. B. A. Viswanath


Peptidomimetics have become immensely important for both the subjects of organic and medicinal chemistry. It is“a molecule bearing identifiable resemblance to a peptide that, as a ligand of a biological receptor, can imitate the effect of natural peptide”. Peptidomimetics have found wide application as bioavailable, and often potent mimetics of natural peptides. They form the basis of important classes of enzyme inhibitors, they act as receptor agonists and antagonists, and they have even been used to mimic DNA structure, their synthesis have become appealing targets for the design because if peptides could be administered as pills they would be potential drugs for many diseases. But lower molecular weight peptides are not suitable as therapeutic agents because they are subject to rapid amide proteolysis. Peptidomimetics can be designed by Conventional solid-phase synthesis, Stereo selective cross-metathesis, Computer-assisted drug design, High-speed Combinatorial chemistry and Peptides-to-Drugs (P2D).The various applications of peptidomimetics are in the area of immunology and treatment of diseases as a receptor antagonists, They are poorly transported to the brain and rapidly excreted through the liver and kidney.

Keywords: Peptidomimetics, Receptor antagonist, Design, 3D structure.

[Full Text Article]

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