Abstract

2,5-DISUBSTITUTED -1,3,4 OXADIAZOLE: MOLECULES OF MULTIFARIOUS APPLICATIONS – A REVIEW

Annapoorna Vadivelu*, A. Nazreen Banu, Y. Nafoura Begam and P. Madhivardhana

ABSTRACT

Oxadiazole or furadiazole are the 5-membered heterocyclic compound containing oxygen and nitrogen. It has become an important construction motif for the development of new drugs. A series of derivatives of 1, 3, 4-oxadiazole having verities of biological activities can be Synthesized by various methods. The activities includes anti-cancer, anti-microbial, anti-inflammatory, anti-HIV, anti-tubercular, anti-diabetic, anti-fungal etc. It also attracted the interest in medicinal chemistry as surrogates (bioisosteres) for carboxylic acids, esters, and carbamides. The review presents a brief summary of the chemistry, synthesis and a broad view on the various pharmacological activities possessed by different compounds substituted with 1,3,4-oxadiazole nucleus.

Keywords: 2,5-disubstituted -1,3,4 oxadiazole, chemistry, synthesis and biological activities.