Abstract

A REVIEW ON QUINOLINE HYBRIDS

Deepali Jagdale* and Priyanka Patil

ABSTRACT

According to World Health Organisation cancer, malaria and tuberculosis come under the list of diseases causing high rates of mortality. Numerous drugs are currently available for treatment of these diseases but they come with major drawback like multidrug resistance and serious side effects. Molecular hybridization can be the new strategy to overcome the problems related with mutation causing resistance, adverse drug reactions, improve activity, affinity etc. This hybridization is the combination of two or more bioactive moieties to create a single molecular structural design with improved affinity and activity. These have emerged as a favourable strategy in recent drug discovery research. This article provides the overview of current developments in hybridization of drugs related to these fatal diseases.

Keywords: Molecular hybridization, Quinoline derivatives, Anti-cancer, Anti-TB, Anti-malarial.